General Information

  • ID:  hor005042
  • Uniprot ID:  P84370(1-14)
  • Protein name:  Pyrokinin-6
  • Gene name:  NA
  • Organism:  Eurycotis floridana (Florida woods cockroach) (Skunk roach)
  • Family:  pyrokinin family
  • Source:  animal
  • Expression:  Expressed in the brain, subesophageal ganglion and in the retrocerebral complex (mainly corpora allata).
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Eurycotis (genus), Eurycotiinae (subfamily), Blattidae (family), Blattoidea (superfamily), Blattodea (order), Dictyoptera (superorder), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005184 neuropeptide hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  GDSEVPGMWFGPRL
  • Length:  14(1-14)
  • Propeptide:  GDSEVPGMWFGPRL
  • Signal peptide:  NA
  • Modification:  T14 Leucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Myoactive
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005042_AF2.pdbhor005042_ESM.pdb

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Physical Information

Mass: 177980 Formula: C70H102N18O20S
Absent amino acids: ACHIKNQTY Common amino acids: G
pI: 4.18 Basic residues: 1
Polar residues: 4 Hydrophobic residues: 4
Hydrophobicity: -35 Boman Index: -1441
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 48.57
Instability Index: 4517.14 Extinction Coefficient cystines: 5500
Absorbance 280nm: 423.08

Literature

  • PubMed ID:  15626499
  • Title:  Peptidomics of neurohemal organs from species of the cockroach family Blattidae: how do neuropeptides of closely related species differ?